The Role of Cognitive-Behavioral Therapy and Fluoxetine in Prevention of...
AbstractThis study evaluated the role of cognitive-behavioral therapy (CBT) and fluoxetine in preventing recurrence of a depressive episode during maintenance phase treatment for patients with remitted...
View ArticleToward a Mechanistic Understanding of How Variability in Neurobiology Shapes...
AbstractResearch has begun to identify how variability in brain function contributes to individual differences in complex behavioral traits. Examining variability in molecular signaling pathways with...
View ArticlePerceived Stress, Anhedonia and Illusion of Control: Evidence for Two...
AbstractIllusion of control (IOC) refers to the perception that one has control over an outcome that is, in actuality, uncontrollable; low IOC has been linked to depression. Prior studies in depression...
View ArticleNeural embedding of stress reactivity
A report in this issue of Nature Neuroscience demonstrates that stress in infancy leading to altered cortisol levels in childhood culminates in vulnerability to dysregulated affect in adolescent girls...
View ArticleMapping anhedonia onto reinforcement learning: a behavioural meta-analysis
AbstractBackgroundDepression is characterised partly by blunted reactions to reward. However, tasks probing this deficiency have not distinguished insensitivity to reward from insensitivity to the...
View ArticleThe Genetics, Neurogenetics and Pharmacogenetics of Addiction
AbstractAddictions are prevalent psychiatric disorders that confer remarkable personal and social burden. Despite substantial evidence for their moderate, yet robust, heritability (approx. 50%),...
View ArticleGenetic and Environmental Factors Associated with Cannabis Involvement
AbstractApproximately 50–70 % of the variation in cannabis use and use disorders can be attributed to heritable factors. For cannabis use, the remaining variance can be parsed in to familial and...
View ArticleEarly Environmental Exposures and Contaminants: a Design Framework for...
AbstractIdentifying factors associated with disruptions in early neurodevelopment is imperative for promoting the health and wellbeing of children. We describe a design framework for biospecimen...
View ArticleBrain structure and problematic alcohol use: a test of plausible causation...
AbstractAssociations between brain structure and problematic alcohol use may reflect alcohol-induced toxicity and/or preexisting risk. Here, we applied a latent causal variable approach to genome-wide...
View ArticleUnderstanding Anhedonia from a Genomic Perspective
AbstractAnhedonia, or the decreased ability to experience pleasure, is a cardinal symptom of major depression that commonly occurs within other forms of psychopathology. Supportive of long-held theory...
View ArticleThe Genetically Informed Neurobiology of Addiction (GINA) model
AbstractAddictions are heritable and unfold dynamically across the lifespan. One prominent neurobiological theory proposes that substance-induced changes in neural circuitry promote the progression of...
View ArticleMultivariate genome-wide association meta-analysis of over 1 million subjects...
AbstractGenetic liability to substance use disorders can be parsed into loci that confer general or substance-specific addiction risk. We report a multivariate genome-wide association meta-analysis...
View ArticlePolygenic Risk for Schizophrenia, Major Depression, and Post-traumatic Stress...
AbstractStudies demonstrate that individuals with diagnoses for Major Depressive Disorder (MDD), Post-traumatic Stress Disorder (PTSD), and Schizophrenia (SCZ) may exhibit smaller hippocampal gray...
View ArticleA Phenome-Wide Association Study (PheWAS) of Late Onset Alzheimer Disease...
AbstractGenetic risk for Late Onset Alzheimer Disease (AD) has been associated with lower cognition and smaller hippocampal volume in healthy young adults. However, whether these and other associations...
View ArticleCharacterizing Alcohol Expectancies in the ABCD Study: Associations with...
AbstractAlcohol expectancies (AEs) are associated with likelihood of alcohol initiation and subsequent alcohol use disorders. It is unclear whether genetic predisposition to alcohol use and/or related...
View ArticleSerotonin Transporter Genotype and Action Monitoring Dysfunction: A Possible...
AbstractA variable number of tandem repeats (short (S) vs long (L)) in the promoter region of the serotonin transporter gene (5-HTTLPR) and a functional variant of a single-nucleotide polymorphism...
View ArticleStress-System Genes and Life Stress Predict Cortisol Levels and Amygdala and...
AbstractDepression has been linked to increased cortisol reactivity and differences in limbic brain volumes, yet the mechanisms underlying these alterations are unclear. One main hypothesis is that...
View ArticleGenetic Moderation of Stress Effects on Corticolimbic Circuitry
AbstractStress exposure is associated with individual differences in corticolimbic structure and function that often mirror patterns observed in psychopathology. Gene x environment interaction research...
View ArticleA Functional Interleukin-18 Haplotype Predicts Depression and Anxiety through...
AbstractCommon functional polymorphisms in the gene encoding interleukin-18 (IL18), a cytokine belonging to the IL-1 superfamily that can induce synthesis of several other cytokines, have been...
View ArticleThe addiction risk factor: A unitary genetic vulnerability characterizes...
AbstractSubstance use disorders commonly co-occur with one another and with other psychiatric disorders. They share common features including high impulsivity, negative affect, and lower executive...
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